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    Anaphylaxis to galacto-oligosaccharides (GOS), a prebiotic, has been described in atopic patients following its supplementation in commercial milk formula in South-East Asia. The epidemiology of this usual allergy to a carbohydrate is unknown. This study evaluated the prevalence of allergy to two formulations of commercial GOS, Vivinal™ GOS (vGOS) and Oligomate™ , in an atopic cohort. Atopic subjects (n = 487) from two specialist allergy clinics were surveyed via structured questionnaire and underwent skin prick tests to GOS. Subjects with positive skin prick tests to GOS (n = 30, 6.2%) underwent basophil activation tests, and a subset (n = 13) underwent oral challenge tests to both formulations of GOS. Six subjects had positive challenges to vGOS; and none to Oligomate. By extrapolating the BAT and oral challenge results, the prevalence of allergy to vGOS is estimated at up to 3.5% (95% CI 2.2-5.5%) of our atopic population. Our findings show that GOS allergy may be common amongst atopics in Singapore. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


    J Y Soh, C-H Huang, W C Chiang, G V Llanora, A J Lee, W Loh, Y L C Chin, V Y J Tay, Y H Chan, D Dianne, B W Lee. Anaphylaxis to galacto-oligosaccharides--an evaluation in an atopic population in Singapore. Allergy. 2015 Aug;70(8):1020-3

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    PMID: 25951913

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