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This work aims to observe the efficacy and safety of low-dose rituximab in combination with recombinant human thrombopoietin in treating immune thrombocytopenia (ITP). Fourteen ITP patients were treated four times with 100 mg qw of rituximab in combination with 300 µg/kg/d ih recombinant human thrombopoietin (rhTPO) for 14 d. Platelet count in peripheral blood, serum immunoglobulin, and lymphocyte subgroups by flow cytometry were detected regularly both pre- and post-treatment. Among the 14 patients, seven complete responses, six responses, and one no response were obtained, with an overall response of 93%. Low-dose rituximab in combination with rhTPO is effective in treating ITP.

Citation

Y Li, Y-Y Wang, H-R Fei, L Wang, C-L Yuan. Efficacy of low-dose rituximab in combination with recombinant human thrombopoietin in treating ITP. European review for medical and pharmacological sciences. 2015;19(9):1583-8

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PMID: 26004596

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