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QuickView for CRH (gene)


Gene Symbol:
CRH Homo sapiens Homo sapiens
Full name:
corticotropin releasing hormone
Synonyms:
corticoliberin, corticotropin releasing hormone, corticotropin-releasing factor, CRF
Genomic Location:
Chr 8: 67251173-67253252
Description:
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency h...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Unknown transcription factor binding site geneset 2 Unknown transcription factor binding site geneset 3 CREB1 binding site geneset 1 JUN binding site geneset 1 EVI1 binding site geneset 5 CUTL1 binding site geneset 4 CREB1 binding site geneset 2 FOXQ1 binding site geneset 1 FOXD3 binding site geneset 1 SRY binding site geneset 2
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8
8q13


Transcripts Names
NM_000756
Protein Names
B3KQS4
P06850



GO Molecular Function

hormone receptor binding | receptor binding | corticotropin-releasing hormone activity | hormone activity | binding | neuropeptide receptor binding | corticotropin-releasing hormone receptor 2 binding | peptide hormone receptor binding | protein binding | neuropeptide hormone activity | corticotropin-releasing hormone receptor binding | G-protein coupled receptor binding | corticotropin-releasing hormone receptor 1 binding

GO Biological Process

positive regulation of circadian rhythm | regulation of biological process | regulation of cortisol secretion | negative regulation of multicellular organismal process | positive regulation of behavior | negative regulation of reproductive process | long-term memory | regulation of cellular localization | regulation of localization | regulation of programmed cell death | cellular hormone metabolic process | organic cyclic compound biosynthetic process | response to hormone stimulus | regulation of biological quality | respiratory tube development | defense response | hormone-mediated signaling pathway | multicellular organismal signaling | regulation of circadian sleep/wake cycle | regulation of response to stimulus | cellular process | death | exploration behavior | synaptic transmission | female pregnancy | cellular response to chemical stimulus | regulation of behavior | regulation of system process | regulation of cellular process | parturition | regulation of apoptotic process | regulation of circadian sleep/wake cycle, REM sleep | organic cyclic compound metabolic process | steroid biosynthetic process | circadian sleep/wake cycle process | response to stimulus | regulation of transmembrane transport | response to chemical stimulus | respiratory system development | positive regulation of steroid hormone secretion | positive regulation of circadian sleep/wake cycle, wakefulness | response to stress | negative regulation of circadian rhythm | circadian rhythm | regulation of steroid hormone secretion | programmed cell death | reproduction | regulation of corticosteroid hormone secretion | rhythmic process | positive regulation of hormone secretion | response to endogenous stimulus | circadian sleep/wake cycle | cellular biosynthetic process | cell-cell signaling | synaptic transmission, dopaminergic | apoptotic process | cellular response to hormone stimulus | system development | reproductive process | regulation of signal transduction | multicellular organismal development | hormone biosynthetic process | learning or memory | positive regulation of multicellular organismal process | lipid metabolic process | hormone-mediated apoptotic signaling pathway | regulation of hormone levels | regulation of hormone secretion | positive regulation of secretion | rhythmic behavior | neurological system process | positive regulation of corticosteroid hormone secretion | single-organism process | regulation of circadian sleep/wake cycle, wakefulness | multi-organism process | cognition | biological regulation | biosynthetic process | locomotory behavior | lipid biosynthetic process | regulation of circadian sleep/wake cycle, sleep | endocrine system development | positive regulation of biological process | negative regulation of response to stimulus | cell communication | inflammatory response | regulation of endocrine process | system process | positive regulation of transport | negative regulation of circadian sleep/wake cycle, REM sleep | apoptotic signaling pathway | regulation of receptor activity | response to organic substance | gland development | negative regulation of behavior | response to wounding | anatomical structure development | regulation of multicellular organismal process | metabolic process | primary metabolic process | adrenal gland development | regulation of secretion | behavior | cellular response to stimulus | organic substance metabolic process | neuron-neuron synaptic transmission | cell death | organ development | C21-steroid hormone metabolic process | cellular response to endogenous stimulus | negative regulation of circadian sleep/wake cycle, sleep | regulation of ion transmembrane transport | negative regulation of biological process | positive regulation of glucocorticoid secretion | lung development | memory | steroid metabolic process | regulation of cell communication | signaling | feeding behavior | glucocorticoid metabolic process | single-organism behavior | regulation of molecular function | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | hormone metabolic process | positive regulation of response to stimulus | regulation of N-methyl-D-aspartate selective glutamate receptor activity | regulation of circadian rhythm | regulation of ion transport | regulation of reproductive process | developmental process | multi-organism reproductive process | C21-steroid hormone biosynthetic process | glucocorticoid biosynthetic process | positive regulation of cellular process | tube development | regulation of transport | circadian behavior | locomotory exploration behavior | regulation of glucocorticoid secretion | single-multicellular organism process | single organism signaling | transmission of nerve impulse | regulation of glutamate receptor signaling pathway | regulation of transporter activity | regulation of execution phase of apoptosis | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cortisol secretion | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

extracellular region | extracellular space | extracellular region part