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QuickView for CYP51 (gene)


Gene Symbol:
CYP51A1 Homo sapiens Homo sapiens
Full name:
cytochrome P450, family 51, subfamily A, polypeptide 1
Synonyms:
sterol 14-alpha demethylase, CP51, CYP51, CYPL1, CYPLI, cytochrome P450 51A1, cytochrome P450, 51 (lanosterol 14-alpha-demethylase), cytochrome P450, family 51, subfamily A, polypeptide 1, cytochrome P450-14DM, cytochrome P45014DM, cytochrome P450LI, lanosterol 14-alpha demethylase, lanosterol 14-alpha-demethylase, LDM, P450-14DM, P450L1
Genomic Location:
Chr 7: 91579402-91601946
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the ...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7q21.2





GO Molecular Function

sterol 14-demethylase activity | cation binding | iron ion binding | demethylase activity | binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | electron carrier activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | ion binding | organic cyclic compound binding | tetrapyrrole binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

organic cyclic compound biosynthetic process | sterol 14-demethylase activity | sterol metabolic process | cellular process | cellular response to chemical stimulus | xenobiotic metabolic process | organic cyclic compound metabolic process | steroid biosynthetic process | response to stimulus | response to chemical stimulus | cellular response to xenobiotic stimulus | demethylase activity | alcohol metabolic process | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | sterol biosynthetic process | small molecule metabolic process | biosynthetic process | cholesterol biosynthetic process | lipid biosynthetic process | response to xenobiotic stimulus | metabolic process | primary metabolic process | cholesterol metabolic process | oxidation-reduction process | cellular response to stimulus | organic substance metabolic process | steroid metabolic process | demethylation | cellular metabolic process | oxidoreductase activity

GO Cellular Component

endoplasmic reticulum part | integral to membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic to membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | organelle part | intracellular organelle part | membrane part | cell part | membrane-bounded organelle | organelle | cytoplasmic part | intracellular part | intracellular | membrane