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QuickView for GATA2 (gene)


Gene Symbol:
GATA2 Homo sapiens Homo sapiens
Full name:
GATA binding protein 2
Synonyms:
endothelial transcription factor GATA-2, FLJ45948, GATA binding protein 2, GATA-binding protein 2, NFE1B, MGC2306, MONOMAC, DCML
Genomic Location:
Chr 3: 129680960-129694718
Description:
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3q21.3





GO Molecular Function

sequence-specific DNA binding | regulatory region DNA binding | transcription regulatory region DNA binding | sequence-specific DNA binding RNA polymerase II transcription factor activity | enhancer binding | cation binding | nucleic acid binding | nucleic acid binding transcription factor activity | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | binding | chromatin binding | protein domain specific binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | C2H2 zinc finger domain binding | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | sequence-specific DNA binding transcription factor activity | transcription factor binding | regulatory region nucleic acid binding | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity | RNA polymerase II distal enhancer sequence-specific DNA binding | transition metal ion binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | semicircular canal development | positive regulation of erythrocyte differentiation | brain development | inner ear morphogenesis | regulation of biological process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | homeostasis of number of cells within a tissue | regulation of localization | regulation of biosynthetic process | somatic stem cell maintenance | eosinophil fate commitment | establishment of localization | nucleic acid metabolic process | regulation of immune system process | myeloid cell differentiation | regulation of biological quality | negative regulation of cellular process | sequence-specific DNA binding RNA polymerase II transcription factor activity | positive regulation of developmental process | cell differentiation | cellular macromolecule metabolic process | negative regulation of fat cell differentiation | nervous system development | neurogenesis | regulation of protein modification process | regulation of organelle organization | generation of neurons | tissue homeostasis | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | localization | cell maturation | negative regulation of signaling | neuron development | central nervous system neuron differentiation | immune system development | stem cell maintenance | regulation of histone modification | hemostasis | regulation of megakaryocyte differentiation | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of nucleobase-containing compound metabolic process | diencephalon development | negative regulation of cellular metabolic process | regulation of fat cell differentiation | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | anatomical structure homeostasis | regulation of angiogenesis | regulation of cellular process | regulation of metabolic process | pituitary gland development | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | positive regulation of megakaryocyte differentiation | urogenital system development | regulation of vasculature development | response to stimulus | negative regulation of cell communication | nucleic acid binding transcription factor activity | transport | response to stress | regulation of fat cell proliferation | regulation of macromolecule biosynthetic process | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | multicellular organismal homeostasis | regulation of anatomical structure morphogenesis | macromolecule biosynthetic process | cell differentiation in hindbrain | cellular nitrogen compound metabolic process | regulation of phagocytosis | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | negative regulation of metabolic process | hemopoiesis | cellular biosynthetic process | embryo development | embryonic placenta development | neuron fate commitment | blood coagulation | leukocyte differentiation | central nervous system neuron development | system development | ventral spinal cord development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organismal development | positive regulation of RNA metabolic process | negative regulation of RNA metabolic process | wound healing | regulation of gene expression | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | regulation of multicellular organismal development | organ morphogenesis | regulation of macromolecule metabolic process | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | single-organism process | definitive hemopoiesis | regulation of Notch signaling pathway | negative regulation of nitrogen compound metabolic process | vesicle-mediated transport | regulation of transcription from RNA polymerase II promoter | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | homeostasis of number of cells | stem cell differentiation | eosinophil differentiation | granulocyte differentiation | biological regulation | biosynthetic process | regulation of primary metabolic process | regulation of cellular protein metabolic process | hindbrain development | positive regulation of macromolecule metabolic process | endocrine system development | positive regulation of biological process | sensory organ development | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | negative regulation of nucleobase-containing compound metabolic process | chordate embryonic development | ventral spinal cord interneuron differentiation | regulation of cellular metabolic process | negative regulation of macrophage differentiation | regulation of protein metabolic process | positive regulation of biosynthetic process | inner ear development | homeostatic process | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | positive regulation of transport | coagulation | embryonic morphogenesis | neuron differentiation | embryonic organ morphogenesis | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | sequence-specific DNA binding transcription factor activity | gland development | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | negative regulation of fat cell proliferation | response to wounding | anatomical structure development | regulation of multicellular organismal process | regulation of neural precursor cell proliferation | metabolic process | cell fate commitment | primary metabolic process | regulation of homeostatic process | regulation of peptidyl-lysine acetylation | regulation of RNA biosynthetic process | developmental maturation | regulation of body fluid levels | negative regulation of transcription, DNA-dependent | embryonic organ development | regulation of erythrocyte differentiation | ear development | regulation of vesicle-mediated transport | endocytosis | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | organ development | forebrain development | gene expression | positive regulation of phagocytosis | regulation of chromosome organization | negative regulation of biological process | transcription, DNA-dependent | stem cell development | anatomical structure formation involved in morphogenesis | cell differentiation in spinal cord | regulation of cell communication | regulation of macrophage differentiation | negative regulation of signal transduction | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | cell development | regulation of endocytosis | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | negative regulation of cellular biosynthetic process | regulation of histone acetylation | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | regulation of transport | positive regulation of transcription, DNA-dependent | negative regulation of cell proliferation | negative regulation of neural precursor cell proliferation | cell fate determination | single-multicellular organism process | positive regulation of transcription from RNA polymerase II promoter | heterocycle metabolic process | central nervous system development | negative regulation of cellular macromolecule biosynthetic process | spinal cord development | in utero embryonic development | positive regulation of metabolic process | immune system process | negative regulation of Notch signaling pathway | cellular metabolic process | hemopoietic or lymphoid organ development | placenta development | ear morphogenesis | phagocytosis | positive regulation of endocytosis | positive regulation of angiogenesis | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | regulation of cellular component organization | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | intracellular non-membrane-bounded organelle | intracellular organelle | macromolecular complex | nuclear part | nucleoplasm | organelle part | intracellular organelle part | organelle lumen | cell part | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular organelle lumen | non-membrane-bounded organelle | intracellular part | intracellular | protein complex