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QuickView for TRAP230 (gene)


Gene Symbol:
MED12 Homo sapiens Homo sapiens
Full name:
mediator complex subunit 12
Synonyms:
FGS1, KIAA0192, human opposite paired, HOPA, TRAP230, thyroid hormone receptor-associated protein complex 230 kDa component, thyroid hormone receptor-associated protein, 230 kDa subunit, TNRC11, trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit), trinucleotide repeat-containing gene 11 protein, putative mediator subunit 12, MED12S, mediator complex subunit 12, mediator of RNA polymerase II transcription subunit 12, mediator of RNA polymerase II transcription, subunit 12 homolog, OTTHUMP00000023491, OKS, OPA-containing protein, OPA1, CAG repeat protein 45, CAGH45, ARC240, activator-recruited cofactor 240 kDa component
Genomic Location:
Chr X: 70255131-70279029
Description:
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), alo...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr X
Xq13


Transcripts Names
NM_005120
Protein Names
Q93074
O75557
Q9UND7
Q9UHV6
O15410



GO Molecular Function

beta-catenin binding | transcription factor binding transcription factor activity | hormone receptor binding | RNA polymerase II transcription factor binding transcription factor activity | receptor binding | thyroid hormone receptor binding | binding | protein domain specific binding | nuclear hormone receptor binding | receptor activity | transcription coactivator activity | protein binding | transcription factor binding | ligand-dependent nuclear receptor transcription coactivator activity | protein binding transcription factor activity | RNA polymerase II transcription cofactor activity | transcription cofactor activity | vitamin D receptor binding | protein C-terminus binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | DNA-dependent transcription, initiation | regulation of biological process | transcription factor binding transcription factor activity | positive regulation of macromolecule biosynthetic process | regulation of biosynthetic process | nucleic acid metabolic process | negative regulation of cellular process | cellular macromolecule metabolic process | androgen receptor signaling pathway | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | negative regulation of signaling | positive regulation of nitrogen compound metabolic process | RNA polymerase II transcription factor binding transcription factor activity | regulation of nucleobase-containing compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | negative regulation of cell communication | regulation of macromolecule biosynthetic process | positive regulation of nucleobase-containing compound metabolic process | macromolecule biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of RNA metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of macromolecule metabolic process | regulation of nitrogen compound metabolic process | single-organism process | regulation of transcription from RNA polymerase II promoter | biological regulation | biosynthetic process | regulation of primary metabolic process | positive regulation of macromolecule metabolic process | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | cell communication | regulation of cellular metabolic process | positive regulation of biosynthetic process | transcription coactivator activity | regulation of RNA metabolic process | regulation of cellular biosynthetic process | metabolic process | primary metabolic process | regulation of RNA biosynthetic process | ligand-dependent nuclear receptor transcription coactivator activity | cellular response to stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | regulation of Wnt receptor signaling pathway | negative regulation of biological process | transcription initiation from RNA polymerase II promoter | transcription, DNA-dependent | intracellular receptor mediated signaling pathway | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-dependent | protein binding transcription factor activity | cellular macromolecule biosynthetic process | RNA polymerase II transcription cofactor activity | intracellular steroid hormone receptor signaling pathway | positive regulation of cellular process | positive regulation of transcription, DNA-dependent | transcription cofactor activity | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | heterocycle metabolic process | positive regulation of metabolic process | negative regulation of Wnt receptor signaling pathway | cellular metabolic process | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | macromolecular complex | nuclear part | nucleoplasm | organelle part | intracellular organelle part | organelle lumen | mediator complex | nucleoplasm part | cell part | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular organelle lumen | intracellular part | intracellular | protein complex