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QuickView for VEGFA (gene)


Gene Symbol:
VEGFA Homo sapiens Homo sapiens
Full name:
vascular endothelial growth factor A
Synonyms:
MVCD1, MGC70609, vascular endothelial growth factor A, vascular endothelial growth factor isoform VEGF165, vascular permeability factor, VEGF, VEGF-A, VPF, RP1-261G23.1
Genomic Location:
Chr 6: 43845931-43862202
Description:
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TCF3 binding site geneset 1 TFAP4 binding site geneset 1 Unknown transcription factor binding site geneset 3 SP1 binding site geneset 1 NFIL3 binding site geneset 1 Unknown transcription factor binding site geneset 16 Unknown transcription factor binding site geneset 20 HNF4A binding site geneset 2 CEBPA binding site geneset 4 EGR1 binding site geneset 1
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 6
6p12





GO Molecular Function

platelet-derived growth factor receptor binding | vascular endothelial growth factor receptor 1 binding | receptor binding | carbohydrate derivative binding | cytokine receptor binding | binding | extracellular matrix binding | identical protein binding | protein heterodimerization activity | vascular endothelial growth factor receptor binding | heparin binding | vascular endothelial growth factor receptor 2 binding | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor agonist activity | cytokine activity | chemoattractant activity | glycosaminoglycan binding | growth factor receptor binding | receptor activator activity | fibronectin binding | cell surface binding

GO Biological Process

regulation of leukocyte chemotaxis | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of biological process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | positive regulation of behavior | exocytosis | regulation of peptidyl-tyrosine autophosphorylation | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | developmental process involved in reproduction | muscle tissue development | ovarian follicle development | regulation of cell development | regulation of localization | morphogenesis of an epithelium | induction of positive chemotaxis | regulation of biosynthetic process | positive regulation of sequence-specific DNA binding transcription factor activity | positive regulation of cell communication | gonad development | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | erythrocyte homeostasis | eye development | negative regulation of cysteine-type endopeptidase activity | smooth muscle cell differentiation | establishment of localization | blood vessel endothelial cell migration | regulation of immune system process | myeloid cell differentiation | platelet degranulation | regulation of cell shape | regulation of biological quality | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of endothelial cell chemotaxis | respiratory tube development | positive regulation of receptor activity | striated muscle cell development | nervous system development | regulation of cell-substrate junction assembly | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of protein modification process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | generation of neurons | cardiac cell development | tissue homeostasis | primitive erythrocyte differentiation | coronary artery morphogenesis | positive regulation of vascular endothelial growth factor receptor signaling pathway | blood vessel morphogenesis | pattern specification process | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | secretion | death | regulation of cell motility | localization | cell maturation | heart morphogenesis | positive regulation of peptidyl-serine phosphorylation | neuron development | regulation of kidney development | reproductive system development | regulation of vascular endothelial growth factor receptor signaling pathway | mesoderm development | immune system development | multicellular organismal reproductive process | positive regulation of protein kinase activity | hemostasis | regulation of chemotaxis | negative regulation of apoptotic process | response to hypoxia | response to growth factor stimulus | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of behavior | tissue development | regulation of cell differentiation | muscle structure development | anatomical structure homeostasis | muscle cell differentiation | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | regulation of response to stress | epithelium development | coronary vasculature morphogenesis | regulation of cell division | urogenital system development | development of primary sexual characteristics | sprouting angiogenesis | lymph vessel morphogenesis | cardiac vascular smooth muscle cell development | positive regulation of stress-activated protein kinase signaling cascade | patterning of blood vessels | regulation of vasculature development | response to stimulus | basophil chemotaxis | VEGF-activated platelet-derived growth factor receptor signaling pathway | vasculature development | muscle cell development | cellular response to vascular endothelial growth factor stimulus | response to chemical stimulus | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | transport | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of protein kinase C signaling cascade | cellular response to hypoxia | response to stress | regulation of macromolecule biosynthetic process | endothelial cell migration | regulation of receptor internalization | post-embryonic camera-type eye development | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | vascular smooth muscle cell differentiation | ovulation cycle | regulation of response to external stimulus | multicellular organismal homeostasis | positive regulation of neuroblast proliferation | tube morphogenesis | cardiac muscle tissue development | regulation of anatomical structure morphogenesis | programmed cell death | development of primary female sexual characteristics | reproduction | cellular localization | secretion by cell | cardiovascular system development | rhythmic process | macrophage differentiation | coronary vein morphogenesis | positive regulation of blood vessel endothelial cell migration | blood circulation | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | hemopoiesis | regulation of mast cell chemotaxis | response to decreased oxygen levels | regulation of cell adhesion | kidney development | embryo development | regulation of morphogenesis of a branching structure | cell chemotaxis | muscle fiber development | activation of protein kinase activity | positive regulation of cell-matrix adhesion | eye photoreceptor cell differentiation | positive chemotaxis | blood vessel development | leukocyte migration | blood coagulation | leukocyte differentiation | regulation of cellular response to stress | locomotion | apoptotic process | chemical homeostasis within a tissue | system development | response to oxygen levels | reproductive process | regulation of signal transduction | regulation of endothelial cell chemotaxis | regulation of stress-activated protein kinase signaling cascade | post-embryonic organ development | multicellular organismal development | negative regulation of catalytic activity | cell migration | positive regulation of RNA metabolic process | regulation of peptidase activity | regulation of MAPK cascade | negative regulation of RNA metabolic process | mammary gland development | taxis | positive regulation of multicellular organismal process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | embryonic hemopoiesis | lymph vessel development | regulation of phosphorylation | negative regulation of peptidase activity | wound healing | monocyte differentiation | regulation of receptor-mediated endocytosis | artery development | response to abiotic stimulus | positive regulation of receptor-mediated endocytosis | mammary gland lobule development | regulation of gene expression | positive regulation of chemotaxis | platelet activation | platelet-derived growth factor receptor signaling pathway | outflow tract morphogenesis | cellular response to stress | regulation of protein autophosphorylation | myeloid leukocyte differentiation | coronary vasculature development | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of multicellular organismal development | organ morphogenesis | regulation of macromolecule metabolic process | positive regulation of p38MAPK cascade | regulation of transferase activity | cellular response to oxygen levels | vascular endothelial growth factor signaling pathway | regulation of nitrogen compound metabolic process | single-organism process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of vascular permeability | negative regulation of nitrogen compound metabolic process | positive regulation of intracellular protein kinase cascade | cardiac cell differentiation | positive regulation of protein complex assembly | vesicle-mediated transport | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | regulation of cellular component movement | regulation of transcription from RNA polymerase II promoter | primitive hemopoiesis | positive regulation of mast cell chemotaxis | regulation of cell migration involved in sprouting angiogenesis | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell differentiation | regulation of endothelial cell migration | homeostasis of number of cells | positive regulation of cell migration | biological regulation | regulation of primary metabolic process | cellular component movement | regulation of cellular protein metabolic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | angiogenesis | surfactant homeostasis | positive regulation of response to external stimulus | positive regulation of macromolecule metabolic process | positive regulation of peptidyl-tyrosine autophosphorylation | cardiac muscle fiber development | post-embryonic development | positive regulation of biological process | regulation of leukocyte migration | sensory organ development | ovulation cycle process | regulation of cellular macromolecule biosynthetic process | positive regulation of phosphorus metabolic process | negative regulation of nucleobase-containing compound metabolic process | chordate embryonic development | striated muscle tissue development | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | eye morphogenesis | positive regulation of leukocyte chemotaxis | regulation of protein kinase C signaling cascade | regulation of protein metabolic process | system process | positive regulation of signal transduction | positive regulation of biosynthetic process | vasculogenesis | leukocyte chemotaxis | heart development | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | positive regulation of transport | eye photoreceptor cell development | striated muscle cell differentiation | regulation of cellular response to growth factor stimulus | coagulation | venous blood vessel development | positive regulation of molecular function | neuron differentiation | multicellular organism reproduction | regulation of receptor activity | receptor regulator activity | endothelial cell chemotaxis | positive regulation of focal adhesion assembly | positive regulation of protein modification process | response to organic substance | gland development | tissue morphogenesis | artery morphogenesis | branching morphogenesis of a tube | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | lactation | regulation of kinase activity | response to wounding | regulation of organ morphogenesis | regulation of sequence-specific DNA binding transcription factor activity | regulation of intracellular protein kinase cascade | regulation of focal adhesion assembly | positive regulation of vascular permeability | anatomical structure development | regulation of positive chemotaxis | regulation of multicellular organismal process | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | positive regulation of cell development | regulation of DNA-dependent transcription in response to stress | positive regulation of branching involved in ureteric bud morphogenesis | regulation of RNA biosynthetic process | circulatory system process | developmental maturation | regulation of body fluid levels | negative regulation of transcription, DNA-dependent | negative regulation of programmed cell death | embryonic organ development | regulation of vesicle-mediated transport | chemical homeostasis | body fluid secretion | receptor agonist activity | cellular response to stimulus | single organism reproductive process | regulation of hydrolase activity | cell death | negative regulation of biosynthetic process | chemoattractant activity | negative regulation of gene expression | organ development | regulation of endothelial cell proliferation | positive regulation of cell-substrate adhesion | positive regulation of leukocyte migration | positive regulation of kinase activity | regulation of phosphate metabolic process | negative regulation of biological process | dopaminergic neuron differentiation | positive regulation of endothelial cell migration | growth | cell activation | positive regulation of MAPK cascade | lung development | morphogenesis of a branching epithelium | camera-type eye development | regulation of peptidyl-serine phosphorylation | mammary gland alveolus development | anatomical structure formation involved in morphogenesis | positive regulation of CREB transcription factor activity | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | signaling | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | cell development | positive regulation of cell migration involved in sprouting angiogenesis | regulation of endocytosis | regulation of molecular function | regulation of epithelial cell proliferation | positive regulation of phosphorylation | regulation of transcription from RNA polymerase II promoter in response to stress | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | camera-type eye morphogenesis | positive regulation of response to stimulus | positive regulation of MAP kinase activity | positive regulation of receptor internalization | reproductive structure development | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of mesenchymal cell proliferation | developmental process | response to external stimulus | localization of cell | erythrocyte differentiation | vascular smooth muscle cell development | positive regulation of protein autophosphorylation | negative regulation of cellular biosynthetic process | vascular endothelial growth factor receptor signaling pathway | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | tube development | regulation of transport | positive regulation of transcription, DNA-dependent | regulation of cellular component biogenesis | cell migration involved in sprouting angiogenesis | positive regulation of mesenchymal cell proliferation | photoreceptor cell development | epithelial cell differentiation | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | venous blood vessel morphogenesis | negative regulation of hydrolase activity | regulation of branching involved in ureteric bud morphogenesis | negative regulation of cellular macromolecule biosynthetic process | transmembrane receptor protein tyrosine kinase signaling pathway | cardiac vascular smooth muscle cell differentiation | in utero embryonic development | positive regulation of metabolic process | vascular process in circulatory system | immune system process | hemopoietic or lymphoid organ development | female sex differentiation | photoreceptor cell differentiation | cellular response to organic substance | sex differentiation | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | chemotaxis | receptor activator activity | positive regulation of endocytosis | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | regulation of p38MAPK cascade | positive regulation of gene expression | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | multicellular organismal process | positive regulation of positive chemotaxis | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | extracellular matrix | proteinaceous extracellular matrix | cytoplasmic vesicle | cell | cytoplasmic membrane-bounded vesicle lumen | cytoplasm | intracellular organelle | platelet alpha granule | organelle part | intracellular organelle part | organelle lumen | vesicle | cell part | extracellular region | membrane-bounded organelle | organelle | extracellular space | extracellular region part | cytoplasmic part | membrane-enclosed lumen | cytoplasmic membrane-bounded vesicle | cytoplasmic vesicle part | secretory granule lumen | membrane-bounded vesicle | cell surface | intracellular part | intracellular | membrane | platelet alpha granule lumen | vesicle lumen